Protective Formulations
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Basic Pharma Polymers
Protective Formulations
Protective Formulations
Many APIs are moisture-sensitive and thus need protection against ambient moisture. DHARACOAT E series polymers provide efficient moisture protection and demonstrate to active. Hence ideal choice to protect hygroscopic ingredients, used in tablets, pellets & powders. In brief DHARACOAT E series offers reverse enteric property i.e. immediate release at stomach but permeable & swellable in intestine. E series functions as taste-masking also in oral solid dosage forms.
DHARACOAT E 100 (20% Polymer in IPA Solution)
DHARACOAT E 100
DHARACOAT E 12.5
DHARACOAT E PO
| Polymer | Pharmacopoeia Monograph | Physical Form | Dissolution |
|---|---|---|---|
| DHARACOAT E 100 (20% Polymer in IPA Solution) | USP/NF : Amino Methacrylate Copolymer Ph. Eur. : Basic Butylated Methacrylate Copolymer |
Organic Solution 20% | Soluble in gastric fluid up to pH 5 |
| DHARACOAT E 100 | Granules | ||
| DHARACOAT E 12.5 | Organic Solution 12.5% | Swellable and permeable above pH 5 | |
| DHARACOAT E PO | Powder |
- Plasticizer
It is recommended to add 10-20% plasticizer on dry polymer substance into the COLONCOAT E Series Solution or Dispersion to obtain films adequate flexibility. - Glidant
Glidants like Talc, Micronized amorphous silica and Glycerol Monostearate facilitates spray application to the cores. - Pigments
Opaque white or colored coating can be obtained by adding pigments like Iron Oxide and Lakes. - Solvents For Non Aqueous Base
Isopropyl alcohol and acetone, also mixture of these
Powder : 15/20/35 Kg. in HDPE Drums with double polyethylene linings.
Liquid : 35/60 Kg. in HDPE Carboys.