Sustain-Release Formulations

Most conventional drug products, such as tablets and capsules are formulated to release the active drug immediately after administration to obtain rapid and complete systemic drug absorption. The goal of any drug delivery system is to provide a therapeutic amount of drug to the proper site in desired concentration. COLONCOAT RL/RS/NE series polymers deliver the drug at the absorption site at a controlled rate. These polymers are pH independent but having unique property to sustain the API release due to permeability mechanism.
COLONCOAT RL 100
COLONCOAT RL PO
COLONCOAT RL 12.5
COLONCOAT RL 30D
COLONCOAT RS 100
COLONCOAT RS PO
COLONCOAT RS 12.5
COLONCOAT RS 30D
COLONCOAT NE 30D

Polymer Pharmacopoeia Monograph Physical Form Dissolution
COLONCOAT RL 100 USP/NF : Ammonio Methacrylate Copolymer, Type A
Ph. Eur. : Ammonio Methacrylate Copolymer, Type A
Granules pH independent
COLONCOAT RL PO Powder
COLONCOAT RL 12.5 12.5% Organic Solution
COLONCOAT RL 30D USP/NF : Ammonio Methacrylate Copolymer Dispersion, Type A
Ph. Eur. : Ammonio Methacrylate Copolymer, Type A
30% Aqueous Dispersion pH independent
COLONCOAT RS 100 USP/NF : Ammonio Methacrylate Copolymer, Type B
Ph. Eur. : Ammonio Methacrylate Copolymer, Type B
Granules pH independent
COLONCOAT RS PO Powder
COLONCOAT RS 12.5 12.5% Organic Solution
COLONCOAT RS 30D USP/NF : Ammonio Methacrylate Copolymer Dispersion, Type B
Ph. Eur. : Ammonio Methacrylate Copolymer, Type B
30% Aqueous Dispersion pH independent
COLONCOAT NE 30D USP/NF : Ethyl Acrylate and Methyl Methacrylate Copolymer Dispersion
Ph. Eur. : Polyacrylate Dispersion 30%
30% Aqueous Dispersion pH independent

Powder : 15/20/35 Kg. in HDPE Drums with double polyethylene linings.
Liquid : 20/35/60 Kg. in HDPE Carboys.

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