Protective Formulations

Many APIs are moisture-sensitive and thus need protection against ambient moisture. COLONCOAT E series polymers provide efficient moisture protection and demonstrate to active. Hence ideal choice to protect hygroscopic ingredients, used in tablets, pellets & powders. In brief COLONCOAT E series offers reverse enteric property i.e. immediate release at stomach but permeable & swellable in intestine. E series functions as taste-masking also in oral solid dosage forms.

COLONCOAT E 100 (20% Polymer in IPA Solution)
COLONCOAT E 100
COLONCOAT E 12.5
COLONCOAT E PO

Polymer Pharmacopoeia Monograph Physical Form Dissolution
COLONCOAT E 100 (20% Polymer in IPA Solution) USP/NF : Amino Methacrylate Copolymer
Ph. Eur. : Basic Butylated Methacrylate Copolymer
Organic Solution 20% Soluble in gastric fluid up to pH 5
COLONCOAT E 100 Granules
COLONCOAT E 12.5 Organic Solution 12.5% Swellable and permeable above pH 5
COLONCOAT E PO Powder
  • Plasticizer
    It is recommended to add 10-20% plasticizer on dry polymer substance into the COLONCOAT E Series Solution or Dispersion to obtain films adequate flexibility.
  • Glidant
    Glidants like Talc, Micronized amorphous silica and Glycerol Monostearate facilitates spray application to the cores.
  • Pigments
    Opaque white or colored coating can be obtained by adding pigments like Iron Oxide and Lakes.
  • Solvents For Non Aqueous Base
    Isopropyl alcohol and acetone, also mixture of these

Powder : 15/20/35 Kg. in HDPE Drums with double polyethylene linings.
Liquid : 20/35/60 Kg. in HDPE Carboys.

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